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At this step, microglial secreted molecules: TNFα, IL-1β, NO, VEGFB, or complement factor Cq1, induce A1 reactive astrocyte phenotype [134,202,203], which is associated with diminished homeostatic and metabolic functions, impaired glutamate uptake (resulting in excitotoxicity) and decreased lactate release from astrocytes [15,134]
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